Protein-guided RNA barcoding links transcriptomes to synaptic architecture
Amanda Urke, Michael-John Dolan, Jonah Silverman, Michael TaeWoo Kim, Juan Pineda, Samantha Garcia, Judy Luu, Alex R. Buckley, Vipin Kumar, Binhui Zhao, Ken Y. Chan, Naeem M. Nadaf, Karol S. Balderrama, Don B. Arnold, Beth Stevens, , Evan Z. Macosko
The paper introduces Synapse-seq, a method to link transcriptomes to synaptic architecture by using protein-guided RNA barcoding, revealing new insights into neural connectivity and cell type-specific dendritic structures.
bioRxiv · Feb 27, 2026 · PreprintNeuroscience