Sumit Jamwal

The paper shows that TREM2 deficiency contributes to impaired microglial pruning and hippocampal dysfunction in a mouse model of childhood deprivation, and that TREM2 overexpression can rescue these deficits.

This study shows that early adversity impairs microglial function in male mice, causing synaptic and behavioral deficits, while females show resilience through astrocytic compensation.