Author

Chavdar Slavov

Alexandrovska HospitalORCID 0000-0001-9441-0243Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:GWAS summary statistics· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Research Focus:polygenic risk· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Adam Stuart KibeliD· 3 shared Agnieszka MichaeliD· 3 shared Ali Amin Al OlamaiD· 3 shared Amanda B. SpurdleiD· 3 shared Anders Martin DaleiD· 3 shared Børge Grønne NordestgaardiD· 3 shared Cezary CybulskiiD· 3 shared Christiane Maier· 3 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenetics

Adam Stuart KibelORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography

Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Jacopo Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, , Jörg Standfuss

The paper captures the release of a photopharmacological drug from tubulin using time-resolved serial crystallography and shows how ligand release triggers conformational changes.

Nature Communications · Feb 17, 2023Peer-reviewedMolecular Biology

The effect of sample size on polygenic hazard models for prostate cancer

Roshan A. Karunamuni, Minh‐Phuong Huynh‐Le, Chun Chieh Fan, Rosalind A. Eeles, Douglas F. Easton, Zsofia Kote‐Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, Kenneth Ross Muir, Henrik Grönberg, Fredrik E. Wiklund, Markus Aly, Johanna Schleutker, Csilla Sipeky, Teuvo L.J. Tammela, , Tyler M. Seibert

This paper evaluates how sample size affects polygenic hazard score models for prostate cancer, finding that 20-30k samples are needed for discovery models, but 10k suffice if SNPs are pre-established.

European Journal of Human Genetics · Jun 8, 2020Peer-reviewedGenetics

A genetic hazard score to personalize prostate cancer screening, applied to population data

Minh‐Phuong Huynh‐Le, Chun Chieh Fan, Roshan A. Karunamuni, Eleanor I. Walsh, Emma L. Turner, J. Athene Lane, Richard Michael Martin, David Edgar Neal, Jenny Donovan, Freddie Charles Hamdy, John Kellogg Parsons, Rosalind A. Eeles, Douglas F. Easton, Zsofia Kote‐Jarai, Ali Amin Al Olama, , Tyler M. Seibert

The paper evaluates a polygenic hazard score for prostate cancer screening, showing it improves positive predictive value by adjusting screening age based on genetic risk.

bioRxiv · Apr 26, 2019 · PreprintGenetics

A genetic risk score to guide age-specific, personalized prostate cancer screening

Tyler M. Seibert, Chun Chieh Fan, Yunpeng Wang, Verena Zuber, Roshan A. Karunamuni, John Kellogg Parsons, Rosalind A. Eeles, Douglas F. Easton, Zsofia Kote‐Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, Kenneth Ross Muir, Henrik Grönberg, Fredrik E. Wiklund, Markus Aly, , Anders Martin Dale

This paper develops a genetic risk score to personalize prostate cancer screening age based on polygenic hazard scores and validates its predictive power in a separate dataset.

bioRxiv · Nov 25, 2016 · PreprintGenetics