The paper examines gene-experience correlations in cognitive development using ABCD Study data, finding stronger genetic associations with crystallized intelligence measures and significant mediation by recreational reading.

Psychological Science · May 5, 2023Peer-reviewedNeuroscience

Efficient meta-analysis of multivariate genome-wide association studies with Meta-MOSTest

Aihua Lin, Alexey A. Shadrin, Dennis van der Meer, Guy Hindley, Weiqiu Cheng, Ida Elken Sønderby, Shahram Bahrami, Kevin Sean O’Connell, Zillur Rahman, Nadine Parker, Olav Bjerkehagen Smeland, Chun Chieh Fan, Dominic Holland, Anders Martin Dale, Ole A. Andreassen, Oleksandr Frei

The paper introduces Meta-MOSTest, an extension of MOSTest for meta-analysis of multivariate GWAS, showing it maintains statistical power and type I error control across multiple cohorts.

bioRxiv · Aug 18, 2022 · PreprintBioinformatics

Unique prediction of developmental psychopathology from genetic and familial risk

Robert J. Loughnan, Clare E. Palmer, Carolina Makowski, Wesley Kurt Thompson, Deanna M. Barch, Terry L. Jernigan, Anders Martin Dale, Chun Chieh Fan

The paper examines genetic and familial risk factors for psychopathology in youth, finding shared and unique associations between polygenic risk scores and behavioral measures.

Journal of Child Psychology and Psychiatry · Jun 28, 2022Peer-reviewedGenetic & Genomic Medicine

Microstructural development from 9-14 years: evidence from the ABCD Study

Clare E. Palmer, Diliana Pecheva, John Rehner Iversen, Donald J. Hagler, Leo P. Sugrue, Pierre Nedelec, Chun Chieh Fan, Wesley Kurt Thompson, Terry L. Jernigan, Anders Martin Dale

The paper uses restriction spectrum imaging to analyze age-related microstructural changes in brain diffusion across 9-14 year olds from the ABCD Study, finding increased restricted diffusion in subcortical regions with age.

Developmental Cognitive Neuroscience · Dec 3, 2021Peer-reviewedNeuroscience

Meaningful Effects in the Adolescent Brain Cognitive Development Study

Anthony Steven Dick, Daniel A. Lopez, Ashley L. Watts, Steven G. Heeringa, Chase Reuter, Hauke Bartsch, Chun Chieh Fan, David N. Kennedy, Clare E. Palmer, Andrew T. Marshall, Frank Haist, Samuel W. Hawes, Thomas E. Nichols, Deanna M. Barch, Terry L. Jernigan, , Wesley Kurt Thompson

The paper describes the design and aims of the ABCD Study, discussing challenges in estimating meaningful associations and recommending best practices for research using its data.

NeuroImage · Jun 17, 2021Peer-reviewedNeuroscience

Spatially heterogeneous microstructural development within subcortical regions from 9-13 years

Clare E. Palmer, Diliana Pecheva, John Rehner Iversen, Don J. Hagler, Leo P. Sugrue, Pierre Nedelec, Chun Chieh Fan, Wesley Kurt Thompson, Terry L. Jernigan, Anders Martin Dale

The paper uses RSI to analyze diffusion patterns in subcortical regions of children aged 9-13, finding age-related changes in restricted diffusion metrics across different brain areas.

bioRxiv · Jun 4, 2021 · PreprintNeuroscience

Additional SNPs improve the performance of a polygenic hazard score for prostate cancer

UKGPCS collaborators, Roshan A. Karunamuni, APCB BioResource (Australian Prostate Cancer BioResource), Canary PASS Investigators, Minh‐Phuong Huynh‐Le, Chun Chieh Fan, Wesley Kurt Thompson, Rosalind A. Eeles, Zsofia Kote‐Jarai, Kenneth Ross Muir, Artitaya Lophatananon, Johanna Schleutker, Nora Pashayan, Jyotsna Batra, Henrik Grönberg, , Tyler M. Seibert

This study improves a polygenic hazard score for prostate cancer by adding 120 SNPs, enhancing hazard ratios but not positive predictive value of PSA testing.

Prostate Cancer and Prostatic Diseases · Jan 8, 2021Peer-reviewedGenetic & Genomic Medicine

African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

Roshan A. Karunamuni, Minh‐Phuong Huynh‐Le, Chun Chieh Fan, Wesley Thompson, Rosalind A. Eeles, Zsofia Kote‐Jarai, Kenneth Ross Muir, UKGPCS Collaborators, Artitaya Lophatananon, Catherine M. Tangen, Phyllis J. Goodman, Ian Murchie Thompson, William J. Blot, Wei Zheng, Adam Stuart Kibel, , Tyler M. Seibert

The paper improves a polygenic hazard score for prostate cancer age at diagnosis by adding SNPs specific to African ancestry, enhancing performance in this population.

International Journal of Cancer · Sep 22, 2020Peer-reviewedGenetic & Genomic Medicine

The genetic architecture of the human cerebral cortex

Katrina L. Grasby, Neda Jahanshad, Jodie N. Painter, Lucía Colodro‐Conde, Janita Bralten, Derrek P. Hibar, Penelope A. Lind, Fabrizio Pizzagalli, Christopher R. K. Ching, Mary Agnes B. McMahon, Natalia Shatokhina, Leo Charles Peek Zsembik, Sophia I. Thomopoulos, Alyssa H. Zhu, Lachlan T. Strike, , Yuri Milaneschi

The paper identifies genetic loci associated with human cortical structure and finds genetic correlations with neuropsychiatric disorders.

Science · Mar 19, 2020Peer-reviewedGenetics

Distinct regionalization patterns of cortical morphology are associated with cognitive performance across different domains

Clare E. Palmer, Weiqi Zhao, Robert J. Loughnan, Jingjing Zou, Chun Chieh Fan, Wesley Kurt Thompson, Anders Martin Dale, Terry L. Jernigan

The paper shows that distinct cortical morphology patterns are associated with different cognitive domains in children, highlighting the importance of sociodemographic factors.

bioRxiv · Feb 13, 2020 · PreprintNeuroscience

A genetic hazard score to personalize prostate cancer screening, applied to population data

Minh‐Phuong Huynh‐Le, Chun Chieh Fan, Roshan A. Karunamuni, Eleanor I. Walsh, Emma L. Turner, J. Athene Lane, Richard Michael Martin, David Edgar Neal, Jenny Donovan, Freddie Charles Hamdy, John Kellogg Parsons, Rosalind A. Eeles, Douglas F. Easton, Zsofia Kote‐Jarai, Ali Amin Al Olama, , Tyler M. Seibert

The paper evaluates a polygenic hazard score for prostate cancer screening, showing it improves positive predictive value by adjusting screening age based on genetic risk.

bioRxiv · Apr 26, 2019 · PreprintGenetics