Richard Michael Martin

Germline polygenic score for prostate cancer aggressiveness

This paper develops a germline polygenic score (PRSagg) to predict prostate cancer aggressiveness and validates it across multiple datasets.

From a genomic risk model to clinical trial implementation in a learning health system: the ProGRESS Study

The paper develops a polygenic risk model for prostate cancer using VA data and validates it in external cohorts, showing its clinical utility in risk stratification.

Identifying therapeutic targets for cancer: 2,094 circulating proteins and risk of nine cancers

This study identifies 40 circulating proteins associated with cancer risk using MR and colocalization, highlighting potential therapeutic targets and adverse effects of protein-altering interventions.

Mendelian randomization revealing the protective effect of sodium-glucose cotransporter 2 inhibition on prostate cancer with verified evidence from electronic healthcare and biological data

This paper uses Mendelian randomization and electronic health records to show SGLT2 inhibitors reduce prostate cancer risk, with additional evidence from differential expression analysis.

Epigenetic markers of adverse lifestyle identified among night shift workers

This study identifies epigenetic markers associated with night shift work, showing links to BMI, education, smoking, and accelerated biological aging.

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

This study uses Mendelian randomization to assess the causal effect of sexual behavior on oropharyngeal cancer risk, finding attenuated associations after adjusting for confounders.

Germline TYK2 mutation and cancer risk

The paper uses a genetic variant to assess cancer risk associated with TYK2 inhibition, finding increased risks for lung cancer and non-Hodgkin lymphoma.

Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility

This study uses Mendelian randomization and colocalization to identify 12 genes, three novel, associated with glioma risk across tissues and subtypes.

Additional SNPs improve the performance of a polygenic hazard score for prostate cancer

This study improves a polygenic hazard score for prostate cancer by adding 120 SNPs, enhancing hazard ratios but not positive predictive value of PSA testing.

Mendelian randomisation study exploring the associations of serum folate with pan and site-specific cancers

This paper uses Mendelian randomisation to investigate the causal relationship between genetically predicted serum folate levels and cancer risk, finding little evidence of a causal association.

Insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3) and breast cancer risk: observational and Mendelian randomization analyses

This study examines the association between IGF-1 and breast cancer risk using observational and Mendelian randomization analyses, finding a positive association and suggesting a causal relationship.

Mendelian Randomization Analysis of Circulating Adipokines and C-reactive Protein on Breast Cancer Risk

This study uses Mendelian randomization to assess the causal effects of adipokines and CRP on breast cancer risk, finding a significant link for hepatocyte growth factor but not others.

Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis

This study uses Mendelian randomization to show that higher physical activity levels are associated with lower risks of breast and colorectal cancer.

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

The paper identifies genetic links between impaired pulmonary function and increased lung cancer risk, showing causal relationships through Mendelian randomization and highlighting immune-related pathways.

Repurposing antihypertensive drugs for the prevention of Alzheimer’s disease: a Mendelian Randomization study

This study uses Mendelian randomization to assess if antihypertensive drugs reduce Alzheimer’s disease risk by lowering systolic blood pressure, finding limited evidence of an effect.

A genetic hazard score to personalize prostate cancer screening, applied to population data

The paper evaluates a polygenic hazard score for prostate cancer screening, showing it improves positive predictive value by adjusting screening age based on genetic risk.

MELODI - Mining Enriched Literature Objects to Derive Intermediates

MELODI identifies mechanistic pathways between biomedical concepts by mining literature, generating hypotheses for further investigation.