Author

Patrizia Mazzucato

Broad InstituteORCID 0000-0001-9446-4540Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Amanda Beccard· 1 shared Angelica MessanaiD· 1 shared Bevin P. EngelwardiD· 1 shared Daisy LamiD· 1 shared Dane Z. HazelbakeriD· 1 shared Danielle N. Chow· 1 shared David M. Weingeist· 1 shared Elina ThadhaniiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Amanda Beccard

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2 papers

Recent·Most cited

CometChip Enables Parallel Analysis of Multiple DNA Repair Activities

Jing Ge, Le P. Ngo, Simran Kaushal, Ian Jun Jie Tay, Elina Thadhani, Jennifer E. Kay, Patrizia Mazzucato, Danielle N. Chow, Jessica L. Fessler, David M. Weingeist, Robert William Sobol, Leona D. Samson, Scott Floyd, Bevin P. Engelward

The paper introduces CometChip, a platform for high-throughput parallel analysis of multiple DNA repair activities, demonstrating its effectiveness in assessing repair deficiencies in Base Excision Repair, Nucleotide Excision Repair, and Non-Homologous End Joining.

DNA repair · Jul 10, 2021Peer-reviewedMolecular Biology

Multiplexed and Inducible Gene Modulation in Human Pluripotent Stem Cells by CRISPR Interference and Activation

Dane Z. Hazelbaker, Amanda Beccard, Gabriella Angelini, Patrizia Mazzucato, Angelica Messana, Daisy Lam, Kevin C. Eggan, Lindy E. Barrett

The paper develops a stable, multiplexed CRISPRi/a system in hPSCs using fluorescent piggyBac vectors and inducible dCas9 transgenes to enable precise gene modulation and analysis.

Scientific Reports · Jan 20, 2020Peer-reviewedMolecular Biology