Author
Broad InstituteORCID 0000-0002-3229-4774Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Jenny A. Klein, Suraj Upadhya, Anna J. Nathanson, Dana Silvian, Eric F. Zaniewski, Robert Morris, Wilhelm Haas, Lindy E. Barrett
This study identifies aberrant chromatin remodeling in Trisomy 21 NPCs that impairs neurogenesis and shows that PRC2 inhibition can partially restore neurogenic potential.
bioRxiv · Jun 3, 2026 · PreprintNeuroscience
Rachel A. Battaglia, Sonia Bolshakova, Ilinca Mazureac, Dhara Liyanage, Noah L. Pettinari, Autumn Johnson, Ethan Crouse, Sartaj Habib, Isabel Flessas, Ajay Nadig, Derek Hawes, Matthew Tegtmeyer, Caroline Becker, Sulagna Dia Ghosh, Giulio Genovese, , Ralda Nehme
The paper uses village editing to study how genetic backgrounds affect the impact of schizophrenia-associated mutations in human neurons.
bioRxiv · Nov 8, 2025 · PreprintCell Biology
Martin H. Berryer, Matthew Tegtmeyer, Loïc Binan, Vera Valakh, Anna J. Nathanson, Darina Trendafilova, Ethan Crouse, Jenny A. Klein, Daniel Meyer, Olli P. H. Pietiläinen, Francesca A. Rapino, Samouil L. Farhi, Lee L. Rubin, Steven A. McCarroll, Ralda Nehme, Lindy E. Barrett
This study develops a rapid, scalable method to generate functional human astrocytes from pluripotent stem cells using NGN2 induction, showing high homogeneity and disease relevance.
iScience · May 30, 2023Peer-reviewedNeuroscience
Martin H. Berryer, Gizem Rizki, Anna J. Nathanson, Jenny A. Klein, Darina Trendafilova, Sara G. Susco, Daisy Lam, Angelica Messana, Kristina M. Holton, Kyle W. Karhohs, Beth A. Cimini, Kathleen Lindahl Pfaff, Anne Elizabeth Carpenter, Lee L. Rubin, Lindy E. Barrett
The paper develops an automated high-content synaptic phenotyping platform in human neurons and astrocytes, identifying BET inhibitors as key regulators of synapse assembly.
eLife · Apr 12, 2023Peer-reviewedNeuroscience
Martina Pigoni, Ana Uzquiano, Bruna da Silveira Paulsen, Amanda J. Kedaigle, Sung Min Yang, Panagiotis Symvoulidis, Xian Adiconis, Silvia Velasco, Rafaela Sartore, Kwanho Kim, Ashley Tucewicz, Kalliopi Tsafou, Xin Jin, Lindy E. Barrett, Fei Chen, , Paola Arlotta
The paper investigates how PTEN heterozygous mutations affect different cell types in human cortical organoids and shows that these effects lead to abnormal circuit activity regardless of genetic background.
bioRxiv · Nov 15, 2022 · PreprintNeuroscience
Ralda Nehme, Olli P. H. Pietiläinen, Mykyta Artomov, Matthew Tegtmeyer, Vera Valakh, Leevi Lehtonen, Christina Bell, Tarjinder Singh, Aditi Trehan, J. L. Sherwood, Danielle K. Manning, Emily R. Peirent, Rhea Malik, Ellen J. Guss, Derek Hawes, , Kevin C. Eggan
This study investigates how the 22q11.2 deletion affects gene expression in neural progenitor cells and neurons, linking it to schizophrenia risk through altered presynaptic gene products.
Nature Communications · Jun 27, 2022Peer-reviewedNeuroscience
Sara G. Susco, Mario A. Arias-García, Violeta G. López-Huerta, Amanda Beccard, Anne M. Bara, Jessica Moffitt, Justin A. Korn, Zhanyan Fu, Lindy E. Barrett
This study examines the effects of FMR1 loss on intrinsic membrane excitability in human cortical neurons using isogenic hPSC models, finding early and transient changes in electrophysiological properties.
Developmental Biology · Sep 22, 2020Peer-reviewedNeuroscience
Dane Z. Hazelbaker, Amanda Beccard, Gabriella Angelini, Patrizia Mazzucato, Angelica Messana, Daisy Lam, Kevin C. Eggan, Lindy E. Barrett
The paper develops a stable, multiplexed CRISPRi/a system in hPSCs using fluorescent piggyBac vectors and inducible dCas9 transgenes to enable precise gene modulation and analysis.
Scientific Reports · Jan 20, 2020Peer-reviewedMolecular Biology