Scott Floyd

This paper identifies TBB as a small molecule inhibitor of MESH1 that suppresses ferroptosis in vitro and reduces neuronal death in an Alzheimer's disease model.

This study investigates FLASH radiation effects on rat brain tissue and tumors using a novel high-energy electron beam, finding differential immune responses and microglial changes.

This study shows that KLHL3 and WNK kinases are regulated by O-GlcNAcylation, affecting osmolarity control and ferroptosis, with implications for blood pressure and neuronal health.

This study shows that ATM inhibition with AZD1390 reduces ferroptosis and neuronal death in ischemic stroke models.

This study shows that estrogens enhance tumor-associated macrophage efferocytosis, promoting immunosuppression, and demonstrates that targeting the E2/ER/CX3CR1 axis can reverse this effect and improve radiation therapy.

This study identifies CoA-mediated post-translational modification of TXNRD2 as a novel mechanism regulating the mitochondrial thioredoxin system to protect against ferroptosis.

The paper introduces CometChip, a platform for high-throughput parallel analysis of multiple DNA repair activities, demonstrating its effectiveness in assessing repair deficiencies in Base Excision Repair, Nucleotide Excision Repair, and Non-Homologous End Joining.