Robert William Sobol

This study shows TTFields increase p21 expression and induce cell death in TNBC cells, with enhanced effects when combined with talazoparib.

This study identifies that rAAV toxicity in dividing cells results from depletion of PARP1 and other DNA damage response proteins, leading to replication stress and cell death.

This study shows that UNG deficiency in tumor cells reduces intrinsic inflammatory signaling and alters interferon sensitivity, leading to a modified tumor microenvironment.

This study identifies TRIP12 as a regulator of DNA polymerase β involvement in DNA damage response and repair by controlling its trafficking and chromatin loading.

This study shows that DNA polymerase beta modulates the PARG-mediated replication checkpoint in HNSCC, and combining PARG and ATR/CHK1 inhibitors overcomes resistance.

The paper evaluates WWE and macrodomain proteins as PAR probes in live cells and shows unique PAR dynamics that can modulate the DNA damage response.

The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.

The paper introduces CometChip, a platform for high-throughput parallel analysis of multiple DNA repair activities, demonstrating its effectiveness in assessing repair deficiencies in Base Excision Repair, Nucleotide Excision Repair, and Non-Homologous End Joining.