Tim Underwood

Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett's esophagus through progression to cancer

This study identifies immune cell changes and gene expression patterns in Barrett's esophagus progression to cancer using spatial and multi-omic analyses.

Comparative analysis of protein expression between oesophageal adenocarcinoma and normal adjacent tissue

This study compares protein expression between oesophageal adenocarcinoma and normal adjacent tissue using proteomics to identify differentially expressed proteins and pathways.

Genomic analysis of response to neoadjuvant chemotherapy in esophageal adenocarcinoma

This study identifies genomic features associated with response to neoadjuvant chemotherapy in esophageal adenocarcinoma, finding lower mutation burden and specific copy number alterations linked to resistance.

Low-cost and clinically applicable copy number profiling using repeat DNA

The paper introduces conliga, a method for inferring high-resolution SCNA profiles from a low-cost and simple assay, addressing the need for affordable SCNA analysis in clinical settings.