Author

T. J. Underwood

Primary ORCID profile (0000-0001-9455-2188 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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T. J. UnderwoodiD1 paper · University of Southampton

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. Harrington· 3 shared B. P. Sharpe· 2 shared C. Tse· 2 shared M. Rose-Zerilli· 2 shared R. Parker· 2 shared Z. S. Walters· 2 shared A. A. Ritchie· 1 shared A. Bailey· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

J. Harrington

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Author profile →

5 papers

Recent·Most cited

Patient-Derived Tumor Organoid and Fibroblast Assembloid Models for interrogation of the tumor microenvironment in Esophageal Adenocarcinoma

B. P. Sharpe, L. A. Nazlamova, C. Tse, D. A. Johnston, R. Blyth, O. J. Pickering, B. Grace, J. Harrington, R. Rajak, M. Rose-Zerilli, Z. S. Walters, T. J. Underwood

The paper develops assembloid models of esophageal adenocarcinoma using tumor organoids and fibroblasts to study the tumor microenvironment.

bioRxiv · Jan 2, 2024Cancer Biology

Combination EZH2 inhibition and retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells

E. OBrien, C. Tse, I. Tracy, I. Reddin, J. Selfe, J. Gibson, W. Tapper, R. J. Pengelly, J. Gao, E. Aladowicz, G. Petts, K. Thway, S. Popov, A. Kelsey, T. J. Underwood, , Z. S. Walters

This study shows that combining EZH2 inhibition with retinoic acid treatment reduces RMS cell proliferation by inducing apoptosis or differentiation depending on the RMS subtype.

bioRxiv · Jun 12, 2023 · PreprintCancer Biology

Identification of neoantigens in esophageal adenocarcinoma

B. Nicholas, A. Bailey, K. J. McCann, O. Wood, R. C. Walker, R. Parker, N. Ternette, T. Elliott, T. J. Underwood, P. Johnson, P. Skipp

This study identifies neoantigens in esophageal adenocarcinoma, finding one directly presented HLA-I neoantigen and a predicted HLA-II neoantigen with T-cell responses, highlighting challenges in neoantigen detection.

bioRxiv · May 4, 2022Cancer Biology

Dual Dean entrainment with volume ratio modulation for efficient co-encapsulation: Extreme single-cell indexing

J. Harrington, L. B. Esteban, J. Butement, A. F. Vallejo, S. I. R. Lane, B. Sheth, M. S. A. Jongen, R. Parker, P. S. Stumpf, R. C. G. Smith, B. D. MacArthur, M. J. Rose-Zerilli, M. E. Polak, T. J. Underwood, J. West

This paper introduces Pirouette-seq, a method for efficient single-cell co-encapsulation with improved throughput and signal-to-noise ratio.

bioRxiv · Apr 8, 2021Cell Biology

Modulation of the tumour promoting functions of cancer associated fibroblasts by phosphodiesterase type 5 inhibition increases the efficacy of chemotherapy in human preclinical models of esophageal adenocarcinoma.

A. Hayden, A. Manousopoulou, A. Cowie, R. Walker, B. P. Sharpe, J. Harrington, F. Izadi, E. Kyle, J. H. Saunders, S. L. Parsons, A. A. Ritchie, P. A. Clarke, P. Collier, S. D. Garbis, M. Rose-Zerilli, , T. J. Underwood

This study shows that PDE5 inhibition reduces CAF tumor-promoting effects and enhances chemotherapy efficacy in EAC models.

bioRxiv · Apr 21, 2020 · PreprintCancer Biology