Marilisa Neri

DRUG-seq provides high-throughput, unbiased transcriptomic data for drug discovery, demonstrating reproducibility and mechanism-of-action resolution for diverse compounds.

This study shows that reduced TREM2 proteolytic cleavage in mice increases microglial heterogeneity and accelerates Abeta pathology in Alzheimer's disease.

The paper benchmarks scRNA-seq methods and introduces CellSIUS, a tool that improves detection of rare cell populations and identifies their functional signatures in human stem cell differentiation.