Ottavio Cremona

This study investigates FXN depletion in cerebellar astrocytes, revealing altered calcium responses and antioxidant properties that may contribute to neurodegeneration in Friedreich's ataxia.

This study characterizes two TDP-43 proteinopathy models in mouse neurons, revealing reduced axonal translation, increased oxidative stress, and presynaptic dysfunction linked to mRNA metabolism disruption.

This study maps the spatial-temporal development of glutamatergic neurons in embryonic cerebellar nuclei, revealing significant cellular heterogeneity and distinct subpopulations.

This study shows that ZFP423 is essential for hindbrain choroid plexus development, regulating early patterning and multiciliogenesis through gene expression and cell fate specification.

This study investigates the role of Zfp423 in cerebellar neurogenesis, revealing its domain-specific effects on cell cycle progression, DNA damage response, and Purkinje cell development in mouse models.