Author

Alessandra Pisciottani

Vita-Salute San Raffaele UniversityORCID 0000-0001-8102-0502Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Alessandra Pisciottani1 paper

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Fabio LauriaiD· 2 shared G. Giacomo ConsaleziD· 2 shared Gabriella VieroiD· 2 shared Laura CrociiD· 2 shared Marta MarchiorettoiD· 2 shared Alessandro AmbrosiiD· 1 shared Alessandro ProvenzaniiD· 1 shared Alessandro QuattroneiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Fabio LauriaORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMay 15, 2025

Disruption of ribosome dynamics and mRNA homeostasis triggers a cascading imbalance in protein synthesis in models of Amyotrophic Lateral Sclerosis

Fabio Lauria, Federica Maniscalco, Cecilia Perrucci…·Gabriella Viero

This study investigates how TDP-43 dysregulation disrupts protein synthesis in ALS models by altering ribosome dynamics and mRNA homeostasis, revealing a conserved mechanism across in vitro and in vivo systems.

DOI 10.1101/2025.05.15.654227

humanproteomics

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NeuroscienceFrontiers in Cellular NeurosciencePeer-reviewedNov 13, 2023

Two neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis.

Alessandra Pisciottani, Laura Croci, Fabio Lauria…·G. Giacomo Consalez

This study characterizes two TDP-43 proteinopathy models in mouse neurons, revealing reduced axonal translation, increased oxidative stress, and presynaptic dysfunction linked to mRNA metabolism disruption.

19 citations

mouseexperimental assay

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