José Luís Trejo

This paper develops a preclinical treatment for PTSD using a peptide that blocks CPEB3 amyloid formation, reducing traumatic memory consolidation and PTSD-like symptoms in mice.

The paper shows that environmental enrichment modulates age-related changes in the 3D chromatin interactome of mouse hippocampal neurons, inducing maturation in young mice and partial rejuvenation in old mice.

The paper shows that moderate exercise improves cognitive function and neurogenesis in mice, but these benefits disappear with higher intensity or duration, and that gut microbiota changes mediate these effects.

The paper identifies a unique population of regulatory T cells in the murine meninges that maintain brain homeostasis by suppressing interferon-gamma-producing lymphocytes and preventing hippocampal damage.

This study shows that exercise in mice can transmit cognitive benefits to the second generation through miRNA-mediated mechanisms, even when cellular changes in the first generation are lost.