Lyong Heo

The paper uses patient-derived organoids to study TAM responses to CD47 checkpoint blockade, revealing a conversion to an immunosuppressive SPP1+ phenotype in clear cell renal cell carcinoma.

This study identifies CES1 deficiency as a driver of metabolic reprogramming and endothelial dysfunction in pulmonary arterial hypertension, showing its role in lipid metabolism and oxidative stress.

This study shows that loss of ROR2 leads to endothelial dysfunction in PAH through inappropriate integrin beta 1 activation, impairing barrier integrity and angiogenesis.

This study uses patient-derived colon organoids to identify lipid-related metabolic dysfunction in pediatric ulcerative colitis and shows that PPAR-α inhibition can alleviate metabolic and inflammatory features.

This study identifies six myeloid cell clusters in melanoma using scRNA-seq, finding that M_C1 subtype frequency predicts survival and immunotherapy response.