Author

Zhongren Ding

Shanghai Medical College of Fudan UniversityORCID 0000-0001-9487-4865Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Guanxing PaniD· 2 shared Jianjun Zhang· 2 shared Si ZhangiD· 2 shared Zhiyong QiiD· 2 shared Ge ZhangiD· 1 shared Haoxuan ZhongiD· 1 shared Hu HuiD· 1 shared Jianlin QiaoiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPharmacology & Toxicology

Guanxing PanORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyJournal of the American Heart AssociationPeer-reviewedJun 24, 2025

ER stress-induced TREM2 downregulation exacerbates platelet activation and myocardial infarction in patients with coronary artery disease

Xiaowen Wu, Guanxing Pan, Lin Chang…·Zhongren Ding

This study identifies TREM2 as a signaling hub linking ER stress, immune-inflammation, and platelet hyperactivity in CAD, showing that TREM2 downregulation exacerbates myocardial infarction and that TREM2-activating antibodies may offer therapeutic potential.

7 citationstop 4%

humanproteomics

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Molecular BiologybioRxivPreprintApr 19, 2025

RIP2 inhibits DOCK8-mediated platelet dense granule release and alleviates experimental myocardial infarction

Jianjun Zhang, Guanxing Pan, Yangyang Liu…·Zhongren Ding

This study shows RIP2 inhibits platelet dense granule release and thrombosis, alleviating myocardial infarction through a PRR-independent pathway involving DOCK8 and Cdc42.

DOI 10.1101/2025.04.19.649674

mouseexperimental assay

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