Author

Xiaowen Wu

Tianjin Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:proteomics· 1 Organism:zebrafish· 1

Frequent Co-Authors

Anning Guo· 1 shared Ge ZhangiD· 1 shared Guanxing PaniD· 1 shared Guijun GuaniD· 1 shared Haoxuan ZhongiD· 1 shared Hu HuiD· 1 shared Jianjun Zhang· 1 shared Jianzeng DongiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperEvolutionary Biology

Anning Guo

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2 papers

Recent·Most cited

ER stress-induced TREM2 downregulation exacerbates platelet activation and myocardial infarction in patients with coronary artery disease

Xiaowen Wu, Guanxing Pan, Lin Chang, Yulong Zhang, Yangyang Liu, Wei Zhang, Yifan Guo, Ge Zhang, Haoxuan Zhong, Zhiyong Qi, Jianjun Zhang, Ruyi Xue, She Chen, Hu Hu, Jianzeng Dong, , Zhongren Ding

This study identifies TREM2 as a signaling hub linking ER stress, immune-inflammation, and platelet hyperactivity in CAD, showing that TREM2 downregulation exacerbates myocardial infarction and that TREM2-activating antibodies may offer therapeutic potential.

Journal of the American Heart Association · Jun 24, 2025Peer-reviewedPharmacology & Toxicology

A compromised gsdf signaling leads to gamatogenesis confusion and subfertility in medaka

Guijun Guan, Shumei Xu, Anning Guo, Xiaomiao Zhao, Yingqing Zhang, Kaiqing Sun, Yi Kang, Yuyang Chang, Xiaowen Wu, Liangbiao Chen

This study shows that compromised gsdf signaling causes gametogenesis confusion and subfertility in medaka by altering somatic expression of Fsh/Lh receptors and brain type aromatase.

bioRxiv · Jan 8, 2018 · PreprintEvolutionary Biology