Author

Si Zhang

Shanghai Medical College of Fudan UniversityORCID 0000-0002-5682-4995Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Guanxing PaniD· 2 shared Jianjun Zhang· 2 shared Zhiyong QiiD· 2 shared Zhongren DingiD· 2 shared Ge ZhangiD· 1 shared Haoxuan ZhongiD· 1 shared Hu HuiD· 1 shared Jianlin QiaoiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPharmacology & Toxicology

Guanxing PanORCID

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2 papers

Recent·Most cited

ER stress-induced TREM2 downregulation exacerbates platelet activation and myocardial infarction in patients with coronary artery disease

Xiaowen Wu, Guanxing Pan, Lin Chang, Yulong Zhang, Yangyang Liu, Wei Zhang, Yifan Guo, Ge Zhang, Haoxuan Zhong, Zhiyong Qi, Jianjun Zhang, Ruyi Xue, She Chen, Hu Hu, Jianzeng Dong, , Zhongren Ding

This study identifies TREM2 as a signaling hub linking ER stress, immune-inflammation, and platelet hyperactivity in CAD, showing that TREM2 downregulation exacerbates myocardial infarction and that TREM2-activating antibodies may offer therapeutic potential.

Journal of the American Heart Association · Jun 24, 2025Peer-reviewedPharmacology & Toxicology

RIP2 inhibits DOCK8-mediated platelet dense granule release and alleviates experimental myocardial infarction

Jianjun Zhang, Guanxing Pan, Yangyang Liu, Lin Chang, Liang Hu, Zhiyong Qi, Zhiling Zhang, Yan Zhang, Si Zhang, Jianlin Qiao, Xiaodong Xi, Kesheng Dai, Jianzeng Dong, Zhongren Ding

This study shows RIP2 inhibits platelet dense granule release and thrombosis, alleviating myocardial infarction through a PRR-independent pathway involving DOCK8 and Cdc42.

bioRxiv · Apr 19, 2025 · PreprintMolecular Biology