Author

Lin Chang

Shanghai Medical College of Fudan UniversityORCID 0000-0003-1878-6155Unclaimed ORCID profile · follow to get notified of new preprints

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Lin Chang1 paper · Shanghai Medical College of Fudan University

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Ge ZhangiD· 1 shared Guanxing PaniD· 1 shared Haoxuan ZhongiD· 1 shared Hu HuiD· 1 shared Jianjun Zhang· 1 shared Jianzeng DongiD· 1 shared Ruyi XueiD· 1 shared She CheniD· 1 shared

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2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Ge ZhangORCID

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1 paper

Recent·Most cited

Pharmacology & ToxicologyJournal of the American Heart AssociationPeer-reviewedJun 24, 2025

ER stress-induced TREM2 downregulation exacerbates platelet activation and myocardial infarction in patients with coronary artery disease

Xiaowen Wu, Guanxing Pan, Lin Chang…·Zhongren Ding

This study identifies TREM2 as a signaling hub linking ER stress, immune-inflammation, and platelet hyperactivity in CAD, showing that TREM2 downregulation exacerbates myocardial infarction and that TREM2-activating antibodies may offer therapeutic potential.

7 citationstop 4%

humanproteomics

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