Pan Zhang

A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated in the developing Down syndrome neocortex

This study uses single-nucleus multi-omics to analyze the developing Down syndrome neocortex, identifying dysregulated molecular and gene-regulatory mechanisms affecting neurogenesis and cell specification.

Visuospatial attention exerts opposite modulatory effects on explicit and implicit audiovisual subjective synchrony via the frontoparietal network

This study investigates how visuospatial attention modulates explicit and implicit audiovisual synchrony through distinct neural mechanisms, showing opposite effects on their behavioral and oscillatory correlates.

Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis

The paper identifies cell-type-specific genetic regulation of RNA-editing and alternative polyadenylation in human neural progenitors and neurons, linking these to brain-related traits.

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms

The paper identifies extensive isoform diversity in the developing human neocortex and links it to neuropsychiatric disorder risk mechanisms.

A subcortical switchboard for exploratory, exploitatory, and disengaged states

The paper identifies the median raphe nucleus as a neural hub that flexibly controls behavioral strategies like exploitation, exploration, and disengagement through distinct neuronal populations.

Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain

The paper constructs a cross-ancestry, cell-type-informed gene regulatory atlas of the developing human brain, identifying genetic regulation and linking it to neuropsychiatric disorders.

Neuron-specific transcriptomic signatures indicate neuroinflammation and altered neuronal activity in ASD temporal cortex

The paper identifies neuron-specific transcriptomic changes in ASD temporal cortex, showing neuroinflammation and altered neuronal activity.

Cortical Organoids Model Early Brain Development Disrupted by 16p11.2 Copy Number Variants in Autism

This study uses cortical organoids derived from patients with 16p11.2 CNV to show altered neurodevelopmental processes, including changes in organoid size, neuronal maturation, and migration.

Full-length isoform transcriptome of developing human brain provides new insights into autism

The paper analyzes full-length splicing isoforms in the developing human brain to identify isoform-level changes associated with neurodevelopmental disorders and highlights the importance of studying mutations at the isoform level.

Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia

The paper investigates the role of the complement system and C4A in schizophrenia by analyzing gene co-expression networks and finds that synaptic pathways, not the complement system, are linked to schizophrenia risk.

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

This study shows that Cul3 haploinsufficiency in mice causes social and cognitive deficits, cortical volume reduction, and cytoskeletal defects, which are rescued by RhoA inhibition.