Han Wang

Automating RNA-Ligand Interaction Modeling via a Self-Improving LLM Agent

This paper introduces RLAgent, an LLM-based framework for RNA-ligand interaction modeling that enables interactive, code-free prediction at the RNA region level.

Trends Assessment of the Genetic Mutation Induced Protein-Protein Interaction Variation via Protein Large Language Driven Method

This paper introduces TAPPI, a deep learning framework that assesses trends in protein-protein interaction variations caused by genetic mutations, achieving state-of-the-art performance and biological relevance.

A Comprehensive Assessment of Methylation-Based Age Prediction Methods

This study benchmarks 15 DNA methylation age prediction methods across 142 datasets, finding that model performance depends on training data characteristics and providing a resource for future research.

TMPs Interaction Domain: A Discovery of Structural Universality Among TMPs Interaction Sites Using Deep Learning Method

The paper uses a 3D deep learning model to find structural universality in TMPs interaction regions, achieving an MCC of 0.36.

PsyMuKB: A De Novo Variant Knowledge Base Integrating Transcriptional and Translational Information to Identify Isoform-specific Mutations in Developmental Disorders

Epigenetic Drift of H3K27me3 in Aging Links Glycolysis to Healthy Longevity

This study shows that aging causes H3K27me3 drift, reducing glycolytic gene expression and lifespan, while PRCs-deficiency or glycolytic gene increase improves longevity.