Yongyong Shi

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

The paper introduces ASMaid, a method to detect archaic introgression sequences in human genomes, revealing more complete and diverse archaic segments than previous methods.

RVPSD provides a web database of 154,716 AlphaFold2-predicted RNA viral protein structures from 5,263 species, enabling structural and functional analysis of RNA viral proteomes.

This paper introduces a modular DNA storage system using dynamic DNA bytes that enables reconfigurable, rewritable data storage with CRUD operations and error correction.

This paper introduces a novel DNA synthesis platform, UCOS, capable of efficiently synthesizing long, complex, and repetitive DNA sequences up to 600nt in length.

The China Brain Multi-omics Atlas Project (CBMAP) creates a comprehensive molecular reference map of over 1,000 human brains to address underrepresentation in East Asian populations and advance research on aging and neuropsychiatric disorders.

This study identifies and characterizes immune-related genetic factors in gout, showing their potential as therapeutic targets beyond traditional urate-lowering treatments.

This study presents genome assemblies and analyses of macaques to explore genetic variation, population history, and evolutionary differences between species and humans.

The paper introduces Haplotype Function Score (HFS) to improve genetic association analysis and polygenic prediction by replacing genotypes with functional scores, showing increased causal findings and better cross-ancestry prediction.

The paper identifies structurally divergent regions in primate genomes and quantifies the impact of structural variants across multiple species.

This study identifies Dnajb6 as a gene causing sick sinus syndrome through a phenotype-based genetic screen in zebrafish.

The paper describes a natural marmoset model of generalized epilepsy, showing genetic predisposition and sensitivity to seizure-inducing agents.

This paper identifies 15 novel serum urate loci and links them to 44 genes, revealing new molecular mechanisms of urate control through genomic and eQTL analysis.

This study identifies schizophrenia genetic associations in East Asian and European populations, finding similar genetic effects across ancestries but highlighting challenges in polygenic risk prediction across groups.