Author

Jorge Urresti

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:long-read sequencing· 1

Frequent Co-Authors

Lilia M. IakouchevaiD· 4 shared Akula Bala PramodiD· 3 shared Jonathan L. SebatiD· 3 shared Kevin K. ChauiD· 3 shared Megha AmariD· 3 shared Pan ZhangiD· 3 shared Alysson Renato MuotriiD· 2 shared Cleber A. TrujilloiD· 2 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersNeuroscience

Lilia M. IakouchevaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cortical Organoids Model Early Brain Development Disrupted by 16p11.2 Copy Number Variants in Autism

Jorge Urresti, Pan Zhang, Patricia Morán Losada, Nam‐Kyung Yu, Priscilla Davidson Negraes, Cleber A. Trujillo, Danny Antaki, Megha Amar, Kevin K. Chau, Akula Bala Pramod, Jolene K. Diedrich, Leon Tejwani, Sarah L. Romero, Jonathan L. Sebat, John R. Yates, , Lilia M. Iakoucheva

This study uses cortical organoids derived from patients with 16p11.2 CNV to show altered neurodevelopmental processes, including changes in organoid size, neuronal maturation, and migration.

Molecular Psychiatry · Aug 25, 2021Peer-reviewedNeuroscience

Full-length isoform transcriptome of developing human brain provides new insights into autism

Kevin K. Chau, Pan Zhang, Jorge Urresti, Megha Amar, Akula Bala Pramod, Jiaye Chen, Amy Elizabeth Thomas, Roser Corominas, Guan Ning Lin, Lilia M. Iakoucheva

The paper analyzes full-length splicing isoforms in the developing human brain to identify isoform-level changes associated with neurodevelopmental disorders and highlights the importance of studying mutations at the isoform level.

Cell Reports · Aug 1, 2021Peer-reviewedNeuroscience

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

Megha Amar, Akula Bala Pramod, Nam‐Kyung Yu, Victor Munive Herrera, Lily R. Qiu, Patricia Morán Losada, Pan Zhang, Cleber A. Trujillo, Jacob Ellegood, Jorge Urresti, Kevin K. Chau, Jolene K. Diedrich, Jiaye Chen, Jessica Gutierrez, Jonathan L. Sebat, , Lilia M. Iakoucheva

This study shows that Cul3 haploinsufficiency in mice causes social and cognitive deficits, cortical volume reduction, and cytoskeletal defects, which are rescued by RhoA inhibition.

Molecular Psychiatry · Mar 16, 2021Peer-reviewedNeuroscience

MutPred2: inferring the molecular and phenotypic impact of amino acid variants

Vikas Rao Pejaver, Jorge Urresti, Jose Lugo-Martinez, Kymberleigh A. Pagel, Guan Ning Lin, Hyun-Jun Nam, Matthew E. Mort, D.N. Cooper, Jonathan L. Sebat, Lilia M. Iakoucheva, Sean David Mooney, Predrag Radivojac A

MutPred2 identifies pathogenic amino acid variants, predicts their molecular mechanisms, and validates their functional impact in neurodevelopmental disorders.

Nature Communications · Nov 20, 2020Peer-reviewedBioinformatics