Ian David Hickson

This study uses optical tweezers to measure the mechanical properties of human centromeres, revealing stiffness at low forces and softening under tension, with implications for chromosome segregation.

This study investigates the role of Condensin I in establishing and maintaining mitotic chromosome stiffness and centromeric cohesion through mechanical analysis and live cell imaging.

The paper uses proteomics to analyze protein dynamics during replication origin firing in human cells, identifying NCAPH2 as a novel factor required for efficient origin firing.