Federico Tessadori

Reciprocal repression between Isl1 and Nkx2-5 defines the zebrafish embryonic cardiac pacemaker domain

This study identifies a zebrafish-specific gene regulatory network where Isl1 restricts Nkx2-5 to maintain pacemaker identity, distinct from mammalian mechanisms.

Twisting of the heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process

This study identifies tbx5a as essential for cardiac looping in zebrafish, showing that heart tube twisting depends on intrinsic tissue patterning and is independent of cell addition.

Asymmetric Hapln1a drives regionalised cardiac ECM expansion and promotes heart morphogenesis during zebrafish development

The paper identifies asymmetric Hapln1a expression in zebrafish heart development, showing it drives ECM expansion and promotes asymmetric heart morphogenesis through interaction with laterality cues.

The centriolar satellite protein Cfap53/Ccdc11 facilitates the formation of the first zygotic microtubule organizing center in the zebrafish embryo.

This study shows that Cfap53 is essential for forming the first zygotic microtubule organizing center in zebrafish embryos, but not for later cell divisions.

Actomyosin dynamics, Bmp and Notch signaling pathways drive apical extrusion of proepicardial cells

The paper identifies actomyosin dynamics and Notch/Bmp signaling as drivers of apical extrusion of proepicardial cells in zebrafish during heart development.