NeuroscienceProceedings of the National Academy of SciencesPeer-reviewed
Diet modifies allele-specific phenotypes in Drosophila carrying epilepsy-associated PNPO variants
Wanhao Chi, Atulya Srisudarshan Ram Iyengar, Wenqin Fu…·Xiaoxi Zhuang
This study shows that PNPO variants in Drosophila interact with diet to produce diverse phenotypes, including seizures and lethality, and highlights the utility of a knock-in model for studying human PNPO deficiency.
18 citations