Atulya Srisudarshan Ram Iyengar

Automated identification of ataxia and convulsions in hyperexcitable Shudderer mutants of the Drosophila sodium channel gene paralytic

The paper develops a machine-learning classifier to automate detection of ataxia and convulsions in Drosophila Shu mutants, showing reliable classification of walking and immobilization with moderate sensitivity for uncoordinated movement.

Nckx30c, a Drosophila K+-dependent Na+/Ca2+ exchanger, regulates temperature-sensitive convulsions and age-related neurodegeneration

This study identifies Nckx30c as a Drosophila Na+/Ca2+ exchanger that regulates temperature-sensitive convulsions and age-related neurodegeneration through its role in Ca2+ homeostasis.

A Cell-Autonomous Role for the Vitamin B6 Metabolism Gene PNPO in Drosophila GABAergic Neurons

This study shows that PNPO in GABAergic neurons is cell-autonomous for maintaining brain function and suppressing seizures in Drosophila under vitamin B6 restriction.

Glial expression of Drosophila UBE3A causes spontaneous seizures modulated by 5-HT signaling

This study compares glial and neuronal expression of dube3a in Drosophila, finding only glial expression causes spontaneous seizures modulated by 5-HT signaling.

Intense light unleashes male-male courtship behaviorin wild-type Drosophila

The paper shows intense light triggers male-male courtship behavior in wild-type Drosophila, revealing visual stimulation can override normal olfactory restraint.

Diet modifies allele-specific phenotypes in Drosophila carrying epilepsy-associated PNPO variants

This study shows that PNPO variants in Drosophila interact with diet to produce diverse phenotypes, including seizures and lethality, and highlights the utility of a knock-in model for studying human PNPO deficiency.

Fly seizure EEG: field potential activity in the Drosophila brain

This paper describes a method to record local field potentials (LFPs) in Drosophila brains during seizures, revealing distinct LFP patterns associated with different seizure types.

Differential effects on neuromuscular physiology between Sod loss-of-function mutation and paraquat-induced oxidative stress in Drosophila

This study compares the effects of Sod loss-of-function mutations and paraquat-induced oxidative stress on neuromuscular physiology in Drosophila, finding distinct impacts on neurotransmission.

Distinct aging-vulnerable trajectories of motor circuit functions in oxidation- and temperature-stressed Drosophila

This study identifies age-vulnerable motor circuit functions in Drosophila under oxidative and temperature stress, showing distinct aging patterns and highlighting potential neurophysiological markers.

Pyridox(am)ine 5’-phosphate oxidase deficiency induces seizures in Drosophila melanogaster

This study establishes Drosophila models of PNPO deficiency, showing seizures and lethality linked to low PLP levels, and demonstrates functional conservation between human and fly PNPO.

Distinctions among electroconvulsion- and proconvulsant-induced seizure discharges and native motor patterns during flight and grooming: Quantitative spike pattern analysis in Drosophila flight muscles

The paper quantitatively analyzes spike patterns in Drosophila flight muscles to distinguish electroconvulsion-induced seizures from native motor patterns during flight and grooming.

Two Novel Forms of ERG Oscillation in Drosophila: Age and Activity Dependence

The paper identifies two novel forms of ERG oscillation in Drosophila that are age and activity dependent, observed in multiple species and strains.