Author

Ashok Ranjan Nayak

Thomas Jefferson UniversityORCID 0000-0001-9531-5168Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Alex H. WilliD· 1 shared Angelica Zamudio‐OchoaiD· 1 shared Dmitry TemiakoviD· 1 shared Graham D. LambiD· 1 shared Joshua J. LoboiD· 1 shared Karl HerbineiD· 1 shared Kelly A. DrydeniD· 1 shared Montserrat SamsóiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

Alex H. WillORCID

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2 papers

Recent·Most cited

Molecular BiologyMolecular CellPeer-reviewedAug 1, 2025

Structural Basis for Promoter Recognition and Transcription Factor Binding and Release in Human Mitochondria

Karl Herbine, Ashok Ranjan Nayak, Angelica Zamudio‐Ochoa, Dmitry Temiakov

The paper presents cryo-EM structures of mitochondrial transcription complexes to elucidate promoter recognition, factor release, and transcription initiation mechanisms in human mitochondria.

6 citations

humanexperimental assay

𝕏 PostBluesky

BiophysicsNature CommunicationsPeer-reviewedMay 15, 2024

Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor

Ashok Ranjan Nayak, Warin Rangubpit, Alex H. Will…·Montserrat Samsó

The paper determines cryo-EM structures of RyR1 with Mg2+ and identifies multiple Mg2+ binding sites, revealing its inhibitory mechanism and interaction with gating helices.

25 citations

cryo-EMexperimental assay

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