Jason C. Klein

The paper uses Perturb-seq in epidermal organoids to study non-canonical NF-κB signaling's role in keratinocyte differentiation.

The paper identifies LRP1 as a more accurate biomarker for diagnosing atypical fibroxanthoma and pleomorphic dermal sarcoma compared to existing markers.

This study evaluates how experimental design, orientation, and sequence context affect MPRA results, finding significant differences in regulatory activity measurements.

This paper identifies the AANAT1 gene as the genetic basis for the speck mutation in Drosophila melanogaster, showing that mutations in AANAT1 lead to the speck phenotype through altered dopamine metabolism.

The paper functionally tests osteoarthritis-associated variants to identify regulatory activity, finding six SNPs with differential effects, including rs4730222 increasing HBP1 isoform expression.

The paper characterizes the evolutionary-functional trajectories of liver enhancers in primates by analyzing sequence mutations and their impact on regulatory activity.