Cancer BiologybioRxivPreprint
Co-targeting an AMPK--MAPK axis reprograms CAFs and suppresses PDAC
Ryodai Yamamura, Yusuke Satoh, Junki Fukuda…·Masahiro Sonoshita
This study shows that targeting the AMPK-MAPK axis in cancer-associated fibroblasts suppresses PDAC growth in fly and mouse models by restoring AMPK activity and inhibiting fibroblast activation.
DOI 10.64898/2026.03.16.711738