Alexander Tyakht

The paper introduces Micro-Cm, a restrictase-free method for microbiome-wide chromosome conformation profiling, showing improved plasmid-host association detection in simulated and real gut microbiome samples.

The paper introduces FlaPro, a tool to profile the human gut flagellome, revealing TLR5-related changes in IBD patients.

This study shows that targeting the AMPK-MAPK axis in cancer-associated fibroblasts suppresses PDAC growth in fly and mouse models by restoring AMPK activity and inhibiting fibroblast activation.

This study shows that gut microbiome diversity correlates with infection by multiple soil-transmitted helminths in African populations, using metagenomic sequencing for parasite detection.

This study compares D- and L-lactate consumption by gut microbes, finding distinct microbial communities and metabolic pathways for each isomer.

This study shows that gut microbiome flagellin affects vaccine reactogenicity and can be influenced by diet.

Serial transfer of low-activity mice gut microbiomes to germ-free mice reduced locomotor activity, showing microbiome transmission can influence host traits independently of genetic changes.

This study links medication use to distinct gut microbial features in anxiety and depression, showing antidepressants have a larger effect on microbiota than diagnoses.

This study uses 3C-seq to analyze the chromosome conformation of Thermofilum adornatum, revealing a curved secondary diagonal and A/B compartments without observed loops or plaid patterns.

The paper investigates how 1,6-hexanediol modulates liquid-liquid phase separation and its impact on 3D chromatin organization in living cells.

VERA simulates antibiotic resistance transmission between pathogens and gut microbiota, showing nonlinear dependencies and exponential disease spread with pathogen resistance.

Knomics-Biota provides a web-based tool for exploratory analysis of human gut metagenomic data, enabling users to generate reports and visualize microbiota composition in relation to experimental factors and public datasets.

MetaCherchant analyzes metagenomic data to reconstruct the genomic environment of antibiotic resistance genes, revealing potential transmission mechanisms in gut microbiota.