Masahiro Sonoshita

This study uses a Drosophila model to identify PRKX as a potential therapeutic target in bladder cancer by combining genotype-informed screening with human cell line validation.

This paper enhances homotypic targeting by engineering exosome surfaces with lanthanides, significantly improving cell-exosome interactions and enabling new applications in diagnostics and therapy.

This study shows that targeting the AMPK-MAPK axis in cancer-associated fibroblasts suppresses PDAC growth in fly and mouse models by restoring AMPK activity and inhibiting fibroblast activation.

This study identifies anastrozole's off-target CYP4V2 as a neuroprotective factor in tauopathy models by reducing Tau phosphorylation and oxidative stress.

The paper identifies dual targeting of riboflavin metabolism and MEK as a novel therapeutic strategy for pancreatic cancer by showing synergistic suppression of PDAC xenograft growth.

This paper introduces flow zoometry, a high-throughput screening method for Drosophila, enabling rapid, automated, and high-resolution analysis of whole animals.

The paper develops a platform combining Drosophila models and computational methods to identify novel chemicals targeting a kinase network in Medullary Thyroid Cancer.