Jonathan Y. Lam

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

This study shows that SIX2 and SIX3 regulate functional maturity and fate of human pancreatic β-cells, with SIX2 affecting insulin processing and glucose sensing, and SIX3 influencing gene expression patterns.

This study investigates pig pancreatic islet development, identifying similarities with human islet ontogeny and uncovering signaling pathways relevant to beta-cell maturation.