Romina J. Bevacqua

A genome-wide CRISPR screen identifies regulators of beta cell function involved in type 2 diabetes risk

A genome-wide CRISPR screen in human pancreatic beta cells identifies 580 genes influencing insulin content, supporting 20 candidate type 2 diabetes effector transcripts.

HNF1α transcriptional activation and repression maintain human islet α and β cell function

This study investigates how HNF1A regulates human islet cell function by combining genetic, transcriptomic, and functional assays, revealing its role in maintaining insulin and glucagon secretion.

SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β-cells

This study shows that SIX2 and SIX3 regulate functional maturity and fate of human pancreatic β-cells, with SIX2 affecting insulin processing and glucose sensing, and SIX3 influencing gene expression patterns.

Molecular and genetic regulation of pig pancreatic islet cell development

This study investigates pig pancreatic islet development, identifying similarities with human islet ontogeny and uncovering signaling pathways relevant to beta-cell maturation.