SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β-cells
Romina J. Bevacqua, Jonathan Y. Lam, Heshan S. Peiris, Robert L. Whitener, Seokho Kim, Xueying Gu, Mollie S. H. Friedlander, Seung K. Kim
This study shows that SIX2 and SIX3 regulate functional maturity and fate of human pancreatic β-cells, with SIX2 affecting insulin processing and glucose sensing, and SIX3 influencing gene expression patterns.
bioRxiv · Dec 3, 2020Developmental Biology