Karienn A. de Souza

This study shows that circadian dysregulation caused by shifted light-dark cycles worsens gut microbiome and intestinal barrier issues more in male than female rats, contributing to sex differences in stroke outcomes.

This paper identifies hyperactivity in the mPFC-to-DMS circuit in 5xFAD mice as a cause of cognitive inflexibility, showing that inhibiting this circuit improves cognitive function and reduces Aβ accumulation.

This study shows that the BNST mediates proactive defensive behavior in rats by modulating avoidance responses through chemogenetic activation or inhibition.