Vasiliki Symeonidou

STEER-seq enables pooled single-cell perturbation screening in hiPSCs by using defined genomic integration and barcode tracking to study transcription factor effects on cell identity.

This study shows that resistant clones are rapidly selected in hematopoietic cell compartments with leukemic stem cell potential before relapse in patients treated with ivosidenib combination therapy.

This study develops a polymer-based culture system to expand human haematopoietic stem and progenitor cells while preserving age-related transcriptional programs, enabling research on ageing haematopoiesis.