Chikai Zhou

This study generates genetically identical mammalian oocytes using parthenogenetic double-haploid embryonic stem cells and blastocyst complementation, producing viable and fertile mice with epigenetic defects.

The paper shows that efficient reprogramming in SCNT occurs exclusively in the epiblast, enabling cloned mouse generation through a lineage-specific mechanism.

The paper identifies ISL1's critical role in primate mesoderm formation through a transcriptional atlas and CRISPR experiments in non-human primates.