Jiangwei Lin

Generation of Genetically Identical Mammalian Oocytes from Parthenogenetic Double-Haploid Embryonic Stem Cells

This study generates genetically identical mammalian oocytes using parthenogenetic double-haploid embryonic stem cells and blastocyst complementation, producing viable and fertile mice with epigenetic defects.

An interferon independent innate immune response to double stranded RNA in embryonic stem cells

This study identifies an IFN-independent innate immune response to dsRNA in mESCs, mediated by Dhx9, p53, and Stat1, which defends against dsRNA stresses and ZIKV infection.

Efficient Reprogramming of the Epiblast Enables the Generation of Cloned Mice

The paper shows that efficient reprogramming in SCNT occurs exclusively in the epiblast, enabling cloned mouse generation through a lineage-specific mechanism.

Efficient derivation and transcriptional characterization of mouse extra-embryonic endoderm stem cell lines generated by somatic cell nuclear transfer

This study derives and characterizes mouse extra-embryonic endoderm stem cell lines from somatic cell nuclear transfer, showing high efficiency and distinct gene expression profiles compared to fertilization-derived lines.

SOX17 Is Not Required for the Derivation and Maintenance of Mouse Extraembryonic Endoderm Stem Cell Lines

This study shows that SOX17 is not required for deriving and maintaining mouse XEN cell lines.

The origin of mouse extraembryonic endoderm stem cell lines

This study identifies the cellular origins of mouse XEN cell lines, showing they derive from both extraembryonic endoderm and epiblast lineages in embryos.