Venetoclax Resistance Creates Canonical Pyroptosis Vulnerability in AML
Qiuxia Wang, Shaohua Xu, Jizhen Cai, Qian Peng, Shuting Cao, Yanyan Zhang, Pengfei Lu, Xu Guo, Luzheng Liu, Wenna Fu, Song Shao, Jiazhuo Zhu, Bowen Qing, Hao Li, Kang Liu, , Ganqian Zhu
This study shows that venetoclax resistance in AML creates a vulnerability to canonical pyroptosis, which can be targeted with DPP8/9 inhibitors and NLRP3 activators.
bioRxiv · Oct 16, 2026 · PreprintCancer Biology