This study identifies a type 2 neuroimmune circuit involving IL-4 receptor-dependent DRG responses that modify esophageal inflammation in eosinophilic esophagitis.

Nature Communications · Oct 16, 2026Peer-reviewedImmunology

Effects of C3aR activated mast cells in eosinophilic esophagitis

Simin Zhang, Dalila Cavallaro, Ming Xia, Netali Ben-Baruch Morgenstern, Tetsuo Shoda, Garrett A. Osswald, Scott M. Bolton, Vincent A. Mukkada, Tahereh Mina Derakhshan, Julia L.M. Dunn, Jennifer M. Felton, Mark Rochman, Julie M. Caldwell, Marc E. Rothenberg

This study investigates the role of C3aR-activated mast cells in eosinophilic esophagitis, showing increased degranulation and cytokine release in EoE patients.

bioRxiv · May 23, 2025 · PreprintImmunology

Remote immune processes revealed by immune-derived circulating cell-free DNA

Ilana Fox-Fisher, Sheina Piyanzin, Bracha-Lea Ochana, Agnes Klochendler, Judith Magenheim, Ayelet Peretz, Netanel Loyfer, Joshua Moss, Daniel Cohen, Yaron Drori, Nehemya Friedman, Michal Mandelboim, Marc E. Rothenberg, Julie M. Caldwell, Mark Rochman, , Yuval Dor

The paper uses immune cell type-specific methylation patterns in circulating cell-free DNA to monitor immune dynamics and find that immune-derived cfDNA levels reflect immune homeostasis and predict immune responses to perturbations.

eLife · Nov 26, 2021Peer-reviewedGenomics

Genetic, inflammatory, and epithelial cell differentiation factors control expression of human calpain-14

Daniel E. Miller, Carmy R. Forney, Mark Rochman, Stacey A. Cranert, Jeff E. Habel, Jeffrey K. Rymer, Arthur Lynch, Connor Schroeder, Josh Lee, Amber B. Sauder, Quinton Smith, Mehak Chawla, Michael P. Trimarchi, Xiaoming Lu, Ellen Fjellman, , Leah Claire Kottyan

The paper investigates how genetic, inflammatory, and epithelial cell differentiation factors regulate CAPN14 expression in eosinophilic esophagitis.

G3 Genes Genomes Genetics · Jan 9, 2019Peer-reviewedGenomics