Sean A. Diehl

This study identifies BCR-dependent enhancement (BDE) as a mechanism by which DENV infects B cells, showing that BCR-E protein interactions and dynamin-mediated entry are critical for viral replication in these cells.

This study shows that DENV infection enhances B cells via their BCR, linking ADE potential to B cell susceptibility and highlighting B cells as a key reservoir in immune-mediated DENV enhancement.

The paper identifies a genetic modifier locus, Bphse, that complements resistance to histamine sensitization in mice by analyzing Hrh1 alleles and using network-based methods.