Martina Varisco

Atlantis integrates structural and functional residue-level data for the human proteome, enabling complex queries and analysis of protein interactions and mutations.

This study analyzes mutations in neural signaling pathways across cancers, finding 65% of patients have alterations linked to poor survival and complex pathway interactions.

The paper identifies directional motif pairs that determine TAD boundary compatibility in Drosophila, showing conservation from flies to mammals.

The paper analyzes cell-cell interactions (CCIs) in transcriptomic data, showing they are more co-expressed in cancer and associated with patient survival and immunotherapy response.

The paper shows that Tau affects global gene expression and chromatin structure in early Alzheimer's disease stages through cellular and transcriptomic analysis.

The paper shows that nuclear Tau regulates VGluT1 expression, linking Tau's non-canonical function to glutamatergic synaptic transmission and neurodegeneration.