Giacomo Siano

The paper shows that Tau affects global gene expression and chromatin structure in early Alzheimer's disease stages through cellular and transcriptomic analysis.

The paper shows that aging in killifish brains reduces basic amino acid-rich proteins through translation pausing, not transcription or proteasome issues, revealing a vulnerability in nucleic-acid protein biogenesis.

This study shows that SARS-CoV-2 infection causes Tau phosphorylation and aggregation in neurons, linked to Alzheimer's disease pathology.

The paper shows that nuclear Tau regulates VGluT1 expression, linking Tau's non-canonical function to glutamatergic synaptic transmission and neurodegeneration.