Marco Terrigno

Homophilic wiring principles underpin neuronal network topology in vitro

This study identifies homophilic wiring as a principle governing neuronal network topology in vitro, outperforming traditional models in explaining connectivity patterns.

Tau alters global gene expression affecting chromatin in the early stages of Alzheimer's disease

The paper shows that Tau affects global gene expression and chromatin structure in early Alzheimer's disease stages through cellular and transcriptomic analysis.

Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey

The paper identifies a potent ASO targeting UBE3A-ATS in Angelman syndrome patient neurons, showing long-lasting effects in cynomolgus monkeys.

An Eutherian-Specific microRNA Controls the Translation of Satb2 in a Model of Cortical Differentiation

The paper identifies miR-541 as an Eutherian-specific microRNA that regulates Satb2 translation during cortical development, revealing its role in timing neuronal identity.

Assessment of Antibody Library Diversity through Next Generation Sequencing and Technical Error Compensation.

This paper introduces a PCR-free NGS approach and software (DEAL) to accurately estimate antibody library diversity by accounting for sequencing errors.

MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging

This study shows miR-29 regulates iron homeostasis in the brain by reducing iron uptake, preventing excessive accumulation and age-related damage.