Ivana Jerković

This study identifies a scaffolding element that drives chromatin rewiring during differentiation by modulating 3D structure and transcription.

The paper shows that preformed chromatin topology supports robust Shh transcription during limb development, with CTCF and ZRS alleles influencing enhancer-promoter communication.

The paper investigates TAD function in mice by editing TAD organization, finding that TADs provide robustness but are not essential for gene regulation, and that disease phenotypes arise from re-direction of regulatory contacts.

The paper identifies genome-wide binding sites of posterior HOX-TFs and reveals subgrouping based on sequence specificity and CTCF association.