Daniel M. Ibrahim

The paper shows that the promoter-proximal region is essential for enhancer-promoter compatibility in specific cell types.

This paper introduces one-pot PASTA, a non-viral method for efficient large transgene integration in human T cells using CRISPR and integrases, showing improved performance over existing methods.

This study shows that osmolality changes in bone marrow after fracture enhance mesenchymal stromal cell regeneration by altering ECM viscoelasticity and chromatin structure.

The paper identifies functionally conserved regulatory elements across distantly related vertebrates despite sequence divergence using a synteny-based method.

The paper uses single-cell RNA sequencing to systematically phenotype mouse genetic models, identifying molecular and cellular changes across multiple mutants and wildtypes.

The paper shows that divergent gene expression within TADs is resolved through TAD restructuring and DNA methylation, not enhancer-promoter compatibility or position.

The paper investigates TAD function in mice by editing TAD organization, finding that TADs provide robustness but are not essential for gene regulation, and that disease phenotypes arise from re-direction of regulatory contacts.

The paper uses crowdfunding to sequence a celebrity cat's genome, identifying mutations causing osteopetrosis and polydactyly, and highlights crowdfunding as a funding and communication tool.