Ahmed Ziyyat

This study uses imaging and analysis to reveal the roles of the zona pellucida and perivitelline space in gamete fusion and polyspermy block in mice oocytes.

This study shows that DOT1L regulates chromatin reorganization and gene expression in male germ cells, leading to fertility defects in its absence.

The paper determines the structure of SPACA6, a sperm protein critical for gamete fusion, and identifies it as a founding member of a conserved superfamily of gamete fusion-associated proteins.