Author

Tyler D. R. Vance

University of TorontoORCID 0000-0002-7637-5891Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

Jeffrey E. LeeiD· 2 shared Ahmed ZiyyatiD· 1 shared Alexander SchleifferiD· 1 shared Andrea PauliiD· 1 shared Andreas BlahaiD· 1 shared Clara S. Phan· 1 shared Diana Gawol· 1 shared Dominik HandleriD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersDevelopmental Biology

Jeffrey E. LeeORCID

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2 papers

Recent·Most cited

A conserved fertilization complex of Izumo1, Spaca6, and Tmem81 mediates sperm-egg interaction in vertebrates

Victoria E. Deneke, Andreas Blaha, Yonggang Lu, Johannes P Suwita, Jonne M. Draper, Clara S. Phan, Karin Panser, Alexander Schleiffer, Laurine Jacob, Theresa Humer, Karel Stejskal, Gabriela Krššáková, Elisabeth Roitinger, Dominik Handler, Maki Kamoshita, , Andrea Pauli

The paper identifies a conserved trimeric complex of Izumo1, Spaca6, and Tmem81 essential for sperm-egg interaction in vertebrates, showing their role in male fertility and binding to the egg protein Bouncer.

Cell · Oct 17, 2024Peer-reviewedDevelopmental Biology

SPACA6 structure reveals a conserved superfamily of gamete fusion-associated proteins

Tyler D. R. Vance, Patrick Yip, Elisabet Jiménez, Sheng Li, Diana Gawol, James Byrnes, Isabel Usón, Ahmed Ziyyat, Jeffrey E. Lee

The paper determines the structure of SPACA6, a sperm protein critical for gamete fusion, and identifies it as a founding member of a conserved superfamily of gamete fusion-associated proteins.

bioRxiv · Mar 23, 2022 · PreprintDevelopmental Biology